Resveratrol (Hu Zhang)
Trans-resveratrol is the active form of the polyphenolic compound, referred to as “resveratrol.” The source of resveratrol at Hill Pharma, Inc. is the roots of Polygonum cuspidatum (Hu Zhang). However, resveratrol is also present in grapes, red wine, spruce, and eucalyptus.
Research studies suggest that resveratrol has beneficial properties in cardiovascular disease and it may play a role in cancer prevention. Its principal biological properties include antioxidant, antimutagenic, and anti-inflammatory effects. Much of the evidence for these effects is based on in-vitro (laboratory studies) and the use of resveratrol as a dietary supplement (or functional food additive) does not permit any claims to be made about disease prevention or treatment with resveratrol.
Trans-resveratrol has been shown to interfere variably with blood coagulation and platelet aggregation. These properties determine the need for avoidance of resveratrol together with antiplatelet or anticoagulant drugs. Furthermore, resveratrol has some drug interaction potential by inhibition of cytochrome P450 enzymes (CYP-3A, CYPIA, and CYP2E1). There is a risk of elevation of drug levels that are metabolized by these cytochrome enzymes (e.g. lovastatin, ketoconazole, fexofendine, etc.). Resveratrol is a weak phytoestrogen and should be avoided in the presence of hormone sensitive cancer (e.g. breast, uterine, and ovarian cancer, etc.)